Alzheimer and Parkinson’s diseases can be paid by one protein

16 октября, 2021 от hiteck Выкл

Scientists have demonstrated that toxic plaques in the brain can be removed using a molecular «pump» cleansing neurons. Their discovery can lead to new methods of treating Alzheimer’s disease and Parkinson.

The accumulations of beta-amyloid proteins and Tau in the brain are considered the main sign and the cause of the development of dementia and other neurodegenerative diseases. The aggregation of toxic plaques violate the work of neurons and gradually lead to their death, so most of the modern research in this area is aimed at their destruction.

A group of American scientists from the Southern Methodist University decided to explore the role of Glycoprotein-P protein (PGP), which was previously associated with the possibility of destroying toxic proteins.

Experiments on human cells

The promising of the new treatment strategy confirmed another experiment. It turned out that between PGP and beta-amyloids there is direct interaction. Increased levels of toxins such as protein clusters cause PGP to use more energy to work and vice versa.

«If we were able to stimulate the launch of a larger number of PGP in the hematorecephalic brain barrier, then probably people with predisposition to Alzheimer’s disease would be able to delay the development of dementia or even prevent its offensive,» said the co-author of John Wise.

Currently, the team studies this promising strategy for the treatment of neurodegeneration in preclinical studies.

In other experiments, scientists from New York University presented new experimental therapy, which


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