II recommended 200 new drugs to combat COVID-19

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Scientists went beyond several main target biomarkers SARS-COV-2 and using artificial intelligence and computing biology tools to look at the problem wider. Now they are at their disposal a whole set of drugs approved for man, which can be started to start using COVID-19 for a short time.

Until now, key attention in the search for new potential drugs against COVID-19 was paid to several targets in SARS-COV-2 and the host cell, as well as inflammatory biological paths. A team of Cambridge University used a combination of computing biology and machine learning to create a much larger map of target proteins and biological paths involved in infection. As a result, they

Given that forty drugs are already investigated against COVID-19, it only confirms the loyalty of the selected strategy, made the authors conclusion. The remaining 160 drugs were not previously associated with SARS-COV-2.

«After examining thousands of proteins that play a certain role in infection — directly when infected or as a result of the disease — we managed to create a network that reveals the relationship between them,» the author of Tony Kuzarides commented on.

While scientists allocate the two most promising drugs: sulfasalazine against rheumatoid arthritis and crown disease and antimalarial probe. These and a number of other drugs can soon be replicated against COVID-19.

The developed approach should work and to search for drugs against new SARS-COV-2 strains, as well as against new pathogens, which can lead to outbreaks of the epidemic, the authors are sure.

Meanwhile, some researchers are working to create drugs against COVID-19 from scratch. For example, scientists from Australia


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