Rheumatoid arthritis begins with an intestine microbalance imbalance16 октября, 2021
A new study of British scientists has shown that the imbalance of intestinal microbiotes is associated with the development of a grueling chronic disease, affecting the joints. The discovered mechanism of this relationship indicates new opportunities for developing simple target therapy.
Previous studies have repeatedly pointed to the connection of an imbalance of intestinal microbiotes and rheumatoid arthritis, but it was not yet clear how bacteria affects the inflammation of the joints. Now the team from the University College of London found that damage to the intestinal mucous membrane directly correlates with inflammation of the joints and the severity of rheumatoid arthritis,
First, preclinical experiments on mice models showed that animal intestinal permeability provoked signs of severe arthritis. The scientists then analyzed the data of patients with rheumatoid arthritis and found their increased indicators of certain biomarkers indicating similar lesions of the mucous membrane.
The additional indicator was the accumulation of leukocytes pointing to inflammation, although all the links in the work of the new mechanism still have to be defined.
Further experiments were demonstrated that the restoration of intestinal permeability defects with certain drugs suppresses the inflammation of the joints. «This means that the intestinal mucosa can be an important therapeutic target for developing new therapy for rheumatoid arthritis,» concluded Mauri.
Recently, another group of researchers presented another experimental approach to the treatment of inflammation of the joints. It turned out that the impact of only one protein
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