Scientists have proven the direct relationship between the consumption of red meat and intestinal cancer

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Recycled and red meat officially recognized carcinogenic in 2015. Then scientists from the International Cancer Study Agency rely, mainly to indirect evidence of preclinical experiments and correlation between the diet and the frequency of cancer. Now scientists

The study was attended by 900 patients with colorectal cancer, which before the diagnosis has been reported for many years, they reported scientists about the diet, lifestyle and other potentially important factors of increased risk of cancer. Sequencing DNA of healthy and cancer cells identified certain genetic patterns indicating DNA damage under a meat type of diet.

Scientists have discovered several mutation patterns, including the form of DNA damage called alkylation. This type of damage was largely associated with the consumption of red and treated meat and is not associated with the consumption of birds and fish. From previous studies, scientists knew that the consumption of red meat especially influenced the development of tumors in the distal colon department. Now they found that cancer cells from this intestinal department have higher alkylating damage.

They then determined that the most common mutations with colorectal cancer — Kras G12D, Kras G13D and Pik3ca E545K are also associated with increased alkylation.

«The data indicate that the consumption of red meat can cause alkylating damages that lead to KRAS and PIK3CA mutations that promote cancer development,» said the collaborator of Marios Giannakis.

Prevention of intestinal cancer

Due to the fact that scientists managed to associate patients with alkylation levels, now the doctors may have new opportunities for early diagnosis and cancer prevention. Alkylating mutations can be used as a biomarker to identify people from a group of increased risk or already sick patients at an early stage of the disease. Further research must confirm this opportunity before doctors have accurate laboratory tests for such diagnostics.

In an earlier study, scientists


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