The first vaccine against rheumatoid arthritis fully cured animals


A breakthrough in research work has occurred thanks to the error in the hypothesis of scientists. Now they have the first effective tool that can be a revolution in the therapy of incurable disease.

The team of American researchers from the University of Tolia for many years studied the protein called 14-3-3 Zeta and its role in the nature of rheumatoid arthritis and other autoimmune diseases. According to their hypothesis, 14-3-3 ZETA could be a trigger of the disease, so preclinical experiments were aimed at removing it,

Surprise scientists the result turned out to be exactly the opposite. Removal 14-3-3 ZETA using gene editing technology has not led to an improvement in the state of animals, but on the contrary — the early and severe of the disease.

Then the researchers decided to check whether 14-3-3 Zeta could protect against rheumatoid arthritis. They developed a protein-based vaccine and tested a new method on animals. Therapy led to a rapid, strong and long-lasting response of an innate immune system, providing protection against illness.

Against the background of the development of rheumatoid arthritis, its own immune system begins to attack healthy tissues of the body, destroying, first of all, joints. Currently, patients with rheumatoid arthritis are treated with corticosteroids and immunosuppressive preparations of a wide range of action that are aimed at reducing the inflammatory process. Although this approach brings a certain relief, in the final perspective, the exhaustive condition continues to progress and worsens the quality of human life.

«Now we have a new strategy that can treat and prevent rheumatoid arthritis. The potential for a person is huge here, «the authors concluded. They have already applied for a patent and prepare a new stage of preclinical research to confirm the effectiveness and safety of therapy.

Previously, another group of researchers demonstrated that the cause of rheumatoid arthritis can be an imbalance of intestinal microbiotes. Their work

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