Found protein, fully blocking HIV, Ebola and other viruses


Opening helped to find a vulnerable area of viruses — a point of exit of infected cells. It turned out that the previously unknown gene literally locks viruses inside, protecting healthy cells surrounded. This approach can be a new strategy for developing antiviral drugs against many diseases.

A group of American researchers discovered at mice and monkeys Retrochmp3 gene, which showed antiviral properties against HIV and Ebola. This gene encodes the corresponding protein and disrupts the ability of viruses to exit the infected cell in order to further colonize healthy,

«We were very surprised at how a small slowdown of our cell biology negates the replication of the virus,» the co-author of the study of Nels Elda commented on.

Unlike mice and monkeys, a person has an original CHMP3 gene, which plays a key role in vital cellular processes, including maintaining the integrity of membranes, intercellular communication and cell division. Using CHMP3, scientists also achieved blocking the human immunodeficiency virus, but then the success of the result was replaced by the defeat: the impact violated important cellular functions and led to cell death.

Then the team decided to use another approach. They achieved that human cells began to express Retrochmp3, and then infected their HIV. It worked and blocked the virus, preventing further infection.

From previous studies, scientists know that in addition to HIV, many other viruses also use this path, called ESCRT, to exit cells. Further research should show how much the new approach will be effective to combat them.

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